Molecular signatures associated with early-life exposures molecular signatures associated with early-life exposures: prediction models of later-life outcomes

The first 1,000 days of life - the time spanning roughly between conception and one's second birthday - is a particularly critical period in which it is necessary to provide interventions for maintaining, restoring, and improving health throughout life. In this scenario, it is important to consider the effect of the exposome, a measure of all the exposures of an individual in a lifetime that relate to human health. Accordingly, we will examine how early-life environmental exposure might affect later-life outcomes for children via molecular mechanisms, and how maternal lifestyles can counteract these molecular defects.